| Pair Name | Falcarindiol, Cisplatin | ||
| Phytochemical Name | Falcarindiol (PubChem CID: 5281148 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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| Pair Name | Falcarindiol, Cisplatin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Expression | RAD51 | hsa5888 | |
| Down-regulation | Expression | BRCA1 | hsa672 | |
| Down-regulation | Expression | MDC1 | hsa9656 | |
| Down-regulation | Phosphorylation | STAT3 | hsa6774 | |
| Down-regulation | Expression | PTTG1 | hsa9232 | |
| In Vitro Model | Huh-7 | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_0336 |
| LM3 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_D269 | |
| Result | Our study illustrated that FAD is a potential anticancer drug and strengthens the chemosensitivity of HCC cells to DDP by inhibiting the STAT3/PTTG1 pathway. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Falcarindiol Enhances Cisplatin Chemosensitivity of Hepatocellular Carcinoma via Down-Regulating the STAT3-Modulated PTTG1 Pathway. Front Pharmacol. 2021 May 7;12:656697. doi: 10.3389/fphar.2021.656697. | Click |
